What is advanced mode

In many biomolecule LCMS analyses, the ionisation process can be complex. Ions can be formed can include adducts of metal ions from the mobile phase. Sometimes, simply considering the addition of single sodium or potassium ions, is insufficient. Basic mode operation of BioMS reviewer in such cases, is insufficient.

In Advanced mode, the user can create more complex mixtures of adducts and common fragmentations, that could be included in the total percentage of target-related ms signal.

In addition, it may be useful to be able to assign common impurities by mass difference. It is possible to include common amino acid deletions, or post-translational modifications in the assignment of the ms signals, without including these in the percentage of target-related ms signal. Similarly, with oligonucleotides it is possible to include common deletions/truncations.

Advanced mode settings are stored in csv files, and can be edited, saved, exported or imported.